MSM® DES Sirolimus
SAFETY - EFFICACY - DELIVERABILITY
The MSM Sirolimus Eluting Coronary Stent System convinces with its trusted Cobalt Chromium Platform and the largest size portfolio available.
A fully biodegradable polymer coating containing Sirolimus (Rapamycin), enables controlled drug release preventing early thrombotic events and stent restenosis.
The biocompatible PLGA Polymer provides consistent, controlled and a 100 % drug release. The Polymer degrades 100 % into carbon dioxide and water.
The decreased profile results in an increased flexibility and enables an easy side branch access.
Safety and Efficiency of Sirolimus
Sirolimus acts on G1 phase of cell cycle, preventing cell from entering S phase and inhibiting SMC proliferation and inflammation.
Effective Factor - Drug
Acting on G1 phase or M phase has different effects
Polymer Coating of MSM Sirolimus
PLGA 85/15 Biocompatible Polymer
The thickness of biodegradable polymer-coating is only 5 μm, thinner coating increases the ability and effectiveness of delivery.
Advanced Coating Technology
During the age of DES, it is very important for stent to remain uniform and smooth after deployment.
Advanced Surface treatment & Coating Technology
During expansion
Unique technology for the metal
surface treatment, and
advanced spraying procedure
After expansion
Great anti-deformability
Coating uniform
No collapse
Factor that affects efficacy Polymer Coating
drug releasing pattern would affect the whole process of restenosis
Four courses of intimal repairing can cause restenosis
- Platelet deposition occurring in 15 days after stent implantation
- Leukocyte recruitment occurring in 50 days
- SMC migration/proliferation occurring in 90 days
- Matrix deposition occurring after 120 days
Drug Release Rate
90-days drug releasing time
First 80% of drug dosage can be released in first month. This controlled drug releasing rate can effectively prevent restenosis during intimal repairing progress
MSM Sirolimus Stent Design
Double-helix lengthways structure shape provides excellent deliverability and conformability
Sine wave design of horizontal structure provide uniform scaffolding and excellent support force
Well-balanced Support and Deliverability
| Material | Cobalt Chromium |
| Strut thickness | 65 μm |
| Coating thickness | 3 - 5 μm |
| Metal-artery ratio | 15% - 18% |
| Balloon tip profile | 0.017" (0.43mm) |
| Lowest crossing profile | 0.035" (0.90mm) |
| Recoil | >2% |
A lot of published papers* showed that the use of a thinner strut stent is associated with a significant reduction of angiographic and clinical restenosis after coronary artery stenting.
* “Intracoronary Stenting and Angiographic Results – Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial” , Adnan Kastraiti MD, Albert Schömig MD, 2001; 103:2816-2821, Circulation
* “In-Stent Restenosis in Small Coronary Arteries - Impact of Strut Thickness” , Carlo Briguori MD etc., Vol. 40, No. 3, 2002, Journal of the American College of Cardiology
MSM DES Sirolimus
- Excellent Side Branch Access
open cell design with 3 interlinks per segment
Diameter of mostly used device
- Guidewire: BMW 0.014” (0.36mm)
- Balloon Dilation Catheter: 0.024” (0.61mm)
Delivery system of MSM DES Sirolimus
Nominal inflation pressure is 8 atm
- Hydrophilic coated distal shaft 1.9F shaft with a rapid deflation balloon
- The balloon design optimizes a controlled linear expansion
- A balloon overhang of <5 mm minimises vessel injury outside the stent
Technical Details Stent
| Type of design | open cell design with 3 interlinks per segment |
| Design details | 9 crown per segment |
| Material | Cobalt-Chromium L605 |
| Size Range | 2.25 mm - 4.00 mm |
| Strut thickness | 0.0026" ( 65μm ) |
| Strut width (Main segment) | 0.0028" ( 72μm ) |
| Strut width (interlink) | 0.0023" ( 58μm ) |
| Shortening after expansion | < 2% |
| Recoil | < 5% |
| Sirolimus Matrix Thickness | < 18% |
| 3-5 μm | |
| Guinding Catheter compatibility | 5 F |
Technical Details Catheter
| Usable length | 138 cm |
| Length of the guide wire lumen | 27 cm |
| Material | Balloon |
| Distal shaft | Polyamide, Multi layer tubing |
| Proximal shaft | Stainless Steel with PTFE Coating |
| Shaft size | Proximal |
| Distal | 2.5 F - 2.9 F, depending on balloon size |
| Balloon folding | Balloon sizes 2.25 mm bis 2.5 mm |
| Balloon sizes 2.75 mm to 4.50 mm | 4-fold balloon |
| Marker | Embedded Platinum/ Iridium Marker |
| Tip profile | 0.017" (0.43 mm) |
| Max. recommended guide wire | 0.014" (0.36 mm) |
Specifications of MSM DES Sirolimus
43 and 48 mm long stent, saving for both patients and doctors
Compliance Data
Order Information
